ptyxis has a few features that gnome-terminal doesn't and which are really handy. Namely, being able to list containers running on the system and then being able to select one to get a terminal running inside the container. Not sure that warrants replacing gnome-terminal but it is really handy if you use containers a lot.
The good news is that before writing Ptyxis, I also ported GNOME Terminal to GTK 4 and doubled the performance of VTE. So you know, use whatever you like.