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All depends on the application and the price per base. If it's cheap enough, you can average over more reads, even with higher error rates. The error rate should come down though. I guess the price will also come down a lot.

I think the single molecule approach has both advantages and disadvantages. Also I think that Illumina's technology in some sense also only reads parts of single molecules, and the averaging is done later in-silico, much as the nanopore would do also.



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